In this session, organised by Eurecat they explore the crucial aspects of Artificial Intelligence (AI) that make predictions in stroke care both understandable and reliable. We will discuss how AI models can be designed and evaluated to ensure transparency and trustworthiness in their predictions, ultimately enhancing patient care and medical decision-making. Finally, we will delve into the ethical issues inherent in the process of building, validating, deploying and making decisions through algorithmic systems.